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Memantic is designed as a desktop application and runs well in the latest versions of Google Chrome, Apple Safari and Mozilla Firefox browsers. Additionally, it is possible to use Memantic on iPad models from 2014 onwards (using the default Safari browser).
Enter a medical concept of interest
Start by supplying a medically relevant term, the connections of which you would like to explore. This can be a disease (e.g. migraine), symptom (wheezing), pharmacological agent (diazepam) or even a broader term such as a geographic area (e.g. Cuba). If Memantic can't recognise the term you have entered, a list of closest matching medical concepts will be presented.
Explore the set of related medical concepts
Search results are visualised as a two-dimensional expandable tree, which is centred on the query term. Leaf nodes, coloured orange, yellow or green, represent the medical concepts that are related to the query. Intermediate tree nodes, coloured blue, represent semantic groupings of these concepts. Clicking on an intermediate node will expand it, changing its colour from dark to light blue and revealing all the nodes grouped by it. Clicking on an expanded intermediate node will collapse it again. The nodes can be dragged around and repositioned to maximise the legibility of the nodes' labels.
Filter the medical concepts by type
You can select the type of relationships you want to see, such as "diseases" (the default setting), "pharmacological agents", "therapeutic procedures", and so on. This link type can be selected in the drop down box in the floating toolbox (after ticking the "show all options" checkbox above).
See the list of publications about the relationship between your query and a chosen concept
Clicking on the text label of a leaf node will unveil a panel on the left side of the screen, listing links to scientific articles that contain the association between the leaf's concept and your query. The top of the publication panel contains a horizontally stacked bar chart that gives a visual breakdown of the number of relevant publications by each decade. Clicking on a decade bar will scroll the publication list to the last publication from that decade.
Explore the network of medical relationships by jumping between concepts
Clicking on the circle part of the leaf node will issue a new search query with the text of the node's label, "re-centering" the user interface on the clicked concept. In this fashion, you can explore the network of medical relationships by by jumping from one connected concept to the next.
Node colour and size
Orange nodes represent concept associations that were discovered only in the scientific articles indexed from PubMed. Green nodes are used for associations that were found only in medical encyclopaedias, and yellow nodes are represent associations that have been identified in both data sources.
The size of a leaf node (or its "weight") is a function of the number of publications supporting the association of its concept with the query. The size of an intermediate node represents the sum of the sizes of all leaf nodes that descend from that node. This is a quick way to indicate the amount of available research for a particular association. It is possible to switch off the node weighting by toggling the "node weights" checkbox in the floating toolbar.